Without mods on a carb and you run E85 straight, it has a hard time accelerating as it cant get the AFR correctly.
E85 has less energy content, so the fuel jets need to be bumped up about 3 sizes and up the air-bleed jets 2 sizes usually.
Plus the accelerator/enrichen mix has to be bumped up to supply more too.
I experimented on the simplest form of a carb with all kinds of mixtures: 67 VW Bug single Solex carb.
To take advantage of the 110 Octane level which has nothing to do with energy content, you can run a combination of all these: advanced timing, higher compression or higher boost, higher aggressive cams.
In all my cars from the old carb to the new EFI in my 04 GMC Yukon, I run 50/50 with no mods and it helps with passing smog checks at the tailpipe.
1gal E85 then add 1gal GAS.
If your car runs rich and has alot of HC (hydrocarbons) during smog, this will reduce that number by alot, but this is a sign you should check compression too.
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